Part of the settings are tied to theme Boost, not working with child themes.
If you are using child theme based on Boost, plugin loses some of it's functionality, because some settings seems to be tied to certain absolute theme name.
Inside topcols own renderer.php is the part:

if (strcmp($page->theme->name, 'boost') === 0) {

 $this->bsnewgrid = true;

}

So when using theme only based on 'Boost', and going to Course format settings and changing the 'Column orientation' to 'Horisontal', defining number of columns etc. those settings do not work, because plugin has not created right additional classes for sections like it should (like col-sm-12 col-md-12 col-lg-12)

That's because 'bsnewgrid' has not been actualized under a "wrong" theme name. If you then change the theme to regular Boost, everything works as intended.