Depending on how Moodle itself and each course are configured, there will be a number of blocks on the left side of the page. Typical is a block titled "Administration," which for a student may contain two links:
Screen reader users would hear this:
Skip administration same page link. Hide administration block button. Administration heading level two. Grades link. Courses link.
Why it matters
Blind users' greatest enemy is cruft; in this case a screen reader user will hear 17 words, while a sighted user sees only three. For the blind user to be successful, all these words must be heard and interpreted.
In this particular case, neither of those links needs to be in this block. "Profile" is accessible elsewhere, and "Grades" belongs somewhere prominent, not in a block that can be removed.
In the general case, the utility of the "skip" and "hide" features should be evaluated. They should be kept only if their utility is high.