Breadcrumbs don't contain useful words (e.g., "Site home," "Course home").
Why it matters
Sighted users understand breadcrumbs as a progression, with each item separated by arrow characters. Blind users see a list of links with no explanatory heading and no implied hierarchy.
Add a heading to the breadcrumbs list, hidden from sighted users; e.g., "Breadcrumbs." Provide better labels for standard locations, like the user's home page or the course home page.