To reproduce:

1. Enable eAccelerator.
2. Log in as an admin.
3. Browse to a course and turn on editing.

Fatal error: Invalid opcode 153/1/8. in /var/www/integration/course/renderer.php on line 203
Call Stack

1. Time Memory Function Location
   1 0.0009 760928
   Unknown macro: {main}

   ( ) ../view.php:0
   2 1.4550 76235776 require( '/var/www/integration/course/format/topics/format.php' ) ../view.php:276
   3 1.4568 76241192 format_section_renderer_base->print_multiple_section_page( ) ../format.php:56
   4 1.4705 76246064 core_course_renderer->course_section_add_cm_control( ) ../renderer.php:724
   5 1.5501 83682312 core_course_renderer->course_modchooser( ) ../renderer.php:456

There are a couple of closure style anonymous functions within course/renderer.php.
This issue was noticed with the use of closures within the lti module as per MDL-36060.
Dan has created MDL-39430 to decide the future for us supporting for eAccelerator however for the time being it is probably worth just quickly converting these to lambda style anonymous functions.

Many thanks
Sam