Loading Errors

Please help me!

I got this errors and my site. It has bad display and his menus, file picker, etc are not working anymore.

GET http://www.uig.edu.mx/plataforma/theme/styles.php/clean/1553720993_1/all net::ERR_ABORTED 500 (Internal Server Error)
VM201:29 GET http://www.uig.edu.mx/plataforma/theme/yui_combo.php?rollup/3.17.2/yui-moodlesimple.js net::ERR_ABORTED 500 (Internal Server Error)
javascript-static.js:33 Uncaught ReferenceError: YUI is not defined
at javascript-static.js:33
(anonymous) @ javascript-static.js:33
(index):2244 Uncaught ReferenceError: Y is not defined
at (index):2244
at (index):2264
(anonymous) @ (index):2244
(anonymous) @ (index):2264
require.js:146 GET http://www.uig.edu.mx/plataforma/lib/requirejs.php/1553716043/core/first.js net::ERR_ABORTED 500 (Internal Server Error)
req.load @ require.js:146
load @ require.js:137
load @ require.js:82
fetch @ require.js:82
check @ require.js:83
enable @ require.js:101
enable @ require.js:128
(anonymous) @ require.js:101
(anonymous) @ require.js:36
each @ require.js:28
enable @ require.js:98
init @ require.js:81
(anonymous) @ require.js:124
setTimeout (async)
req.nextTick @ require.js:142
localRequire @ require.js:124
requirejs @ require.js:142
(anonymous) @ (index):1922
require.js:41 Uncaught Error: Script error for "core/first"
http://requirejs.org/docs/errors.html#scripterror
at makeError (require.js:41)
at HTMLScriptElement.onScriptError (require.js:137)
makeError @ require.js:41
onScriptError @ require.js:137
error (async)
req.load @ require.js:144
load @ require.js:137
load @ require.js:82
fetch @ require.js:82
check @ require.js:83
enable @ require.js:101
enable @ require.js:128
(anonymous) @ require.js:101
(anonymous) @ require.js:36
each @ require.js:28
enable @ require.js:98
init @ require.js:81
(anonymous) @ require.js:124
setTimeout (async)
req.nextTick @ require.js:142
localRequire @ require.js:124
requirejs @ require.js:142
(anonymous) @ (index):1922